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MYP_043554
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Basic Information
Brevinin-1SPd
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C99H165N23O22S3
Standard
Sequence
FFPIIAGMAAKVICAITKKC
Physicochemical Analysis
2125.70 Da
9.39
2.74
2.50
0.1369
1.38
0.52
0.44
21.05
112.50
0.1000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
-2.47
26.0
28.0
69.0
147.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007685 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
3 μM
MIC
PaperPurification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
RECORD: Rec_0008048 VERIFIED: YES
Provenance & Taxonomy
Lithobates septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Staphylococcus aureus
PMID15556063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
RECORD: Rec_0050589 VERIFIED: NO
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial Hemolytic
RECORD: Rec_0093073 VERIFIED: YES
Provenance & Taxonomy
Lithobates blairi [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0129553 VERIFIED: NO
Provenance & Taxonomy
Lithobates septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15556063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
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