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MYP_043531
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Basic Information
HR1-a
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
28 amino acids
C135H218N38O49
Standard
Sequence
YENQKQIANQFNKAISQIQESLTTTSTA
Physicochemical Analysis
3157.40 Da
6.14
-0.24
-0.45
-0.0085
-0.85
0.71
-0.12
36.41
66.43
0.0714
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1482.22
-20.64
49.0
49.0
109.0
222.0
2.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0300974 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV‐luc/SARS Pseudotyped Virus:inhibition of viral-entry in Vero E3 cells
1.16 μM
EC50
PaperPubMed PMID: 18442051 PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
RECORD: Rec_0352927 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
1.16 μM
EC50
PaperFusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
RECORD: Rec_0377258 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV PsV: inhibition of HIV-luc/SARS PsV infection in Vero-E6 cells
1.16 μM
EC50
PaperPubMed PMID: 18442051 PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
RECORD: Rec_0382074 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV‐luc/SARS Pseudotyped Virus | E3 cells
1.16 μM
EC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperFusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors. | Chu LH, Chan SH, Tsai SN, Wang Y, Cheng CH, Wong KB, Waye MM, Ngai SM. | J Cell Biochem. 2008 Aug 15;104(6):2335-47. | DOI:10.1002/jcb.21790 | PMID:18442051 PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
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