Peptide Database

Peptide NameSLAY-screened peptide P1257

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length7 amino acids

Chemical FormulaC29H51N9O10S2

DescriptionStandard

        CQVCNAL
    

Molecular Weight749.90 Da

Isoelectric Point (pI)5.51

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.49

Charge Density (pH 7.0) -0.0371

GRAVY Index1.11

Hydrophobic Moment 0.46

Boman Index0.24

Instability Index-12.97

Aliphatic Index 111.43

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 324.10

LogP -3.97

H-bond Donors 12.0

H-bond Acceptors 12.0

Rotatable Bonds 23.0

Heavy Atoms 50.0

Ring Count 0.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0373784 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/