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MYP_043513
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Basic Information
Brevinin-1SY
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C114H197N27O27S2
Standard
Sequence
FLPVVAGLAAKVLPSIICAVTKKC
Physicochemical Analysis
2442.08 Da
9.39
2.74
2.50
0.1141
1.48
0.48
0.44
34.61
146.25
0.0417
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
833.56
-4.01
30.0
32.0
77.0
170.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0111333 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0162872 VERIFIED: YES
Provenance & Taxonomy
Rana sylvatica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
18-24
Also discovered by deep learning. Found in multiple species. Chemical modification: It contains one disulfide bond: 18, 24
Bio-Activity Profile
Antimicrobial
S.enteritidis
>128 μg/mL
MIC
PaperInduction of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli.
RECORD: Rec_0213373 VERIFIED: NO
Provenance & Taxonomy
Wood frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0248533 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 41.7%, E 0.0%, T 29.2%, C 29.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0270391 VERIFIED: YES
Provenance & Taxonomy
Lithobates sylvaticus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID11042268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11042268/
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