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MYP_043513
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Basic Information
Brevinin-1SY
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C114H197N27O27S2
Standard
Sequence
FLPVVAGLAAKVLPSIICAVTKKC
Physicochemical Analysis
2442.08 Da
9.39
2.74
2.50
0.1141
1.48
0.48
0.44
34.61
146.25
0.0417
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
833.56
-4.01
30.0
32.0
77.0
170.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004237 VERIFIED: YES
Provenance & Taxonomy
Rana sylvatica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
18-24
Also discovered by deep learning. Found in multiple species. Chemical modification: It contains one disulfide bond: 18, 24
Bio-Activity Profile
Antimicrobial
Escherichia coli
45 μM
MIC
PaperInduction of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli.
RECORD: Rec_0021550 VERIFIED: YES
Provenance & Taxonomy
Rana sylvatica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
18-24
Also discovered by deep learning. Found in multiple species. Chemical modification: It contains one disulfide bond: 18, 24
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 29213
4-8 μg/mL
MIC
PaperInduction of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli.
RECORD: Rec_0022975 VERIFIED: YES
Provenance & Taxonomy
Rana sylvatica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
18-24
Also discovered by deep learning. Found in multiple species. Chemical modification: It contains one disulfide bond: 18, 24
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922
8-16 μg/mL
MIC
PaperInduction of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli.
RECORD: Rec_0088709 VERIFIED: YES
Provenance & Taxonomy
Rana sylvatica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
18-24
Also discovered by deep learning. Found in multiple species. Chemical modification: It contains one disulfide bond: 18, 24
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
7 μM
MIC
PaperInduction of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli.
RECORD: Rec_0090020 VERIFIED: YES
Provenance & Taxonomy
Lithobates sylvaticus [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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