Peptide Database

Peptide NameDefensin-6 (Defensin; alpha 6)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length100 amino acids

Chemical FormulaC469H741N135O153S8

DescriptionStandard

        MRTLTILTAVLLVALQAKAEPLQAEDDPLQAKAYEADAQEQRGANDQDFAVSFAEDASSSLRALGSTRAFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
    

Molecular Weight10975.23 Da

Isoelectric Point (pI)5.21

Net Charge (pH 7.0)-3.37

Net Charge (pH 7.4) -3.79

Charge Density (pH 7.0) -0.0337

GRAVY Index-0.17

Hydrophobic Moment 0.57

Boman Index-0.02

Instability Index55.34

Aliphatic Index 73.40

Aromaticity 0.0800

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4666.26

LogP -55.35

H-bond Donors 170.0

H-bond Acceptors 160.0

Rotatable Bonds 361.0

Heavy Atoms 765.0

Ring Count 12.0

Amide Bonds 107.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420936 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetListeria monocytogenes (Gram-positive)

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