MYP_043431
B1-L-7
Anticancer
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
15 amino acids
C94H158N28O17
Standard
VKRFKRFFRKLKSLV
1952.44 Da
12.00
6.73
6.51
0.4487
-0.37
1.04
-0.39
29.54
90.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
780.73
-3.38
30.0
24.0
70.0
139.0
3.0
14.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0022498
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
U87
12.70±1.63 μM
IC50
RECORD: Rec_0042641
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Hemolytic
human red blood cells
>80 μM
HC50
RECORD: Rec_0058273
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
13.36±1.22 μM
IC50
RECORD: Rec_0118519
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
Huh-7
7.49±1.2 μM
IC50