Peptide Database

Peptide NameHuman islet amyloid polypeptide

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC169H273N51O57S2

DescriptionStandard

        RCNTATCVTQRLADFLVRSSNTIGAIYSPTNVGSNTY
    

Molecular Weight3995.41 Da

Isoelectric Point (pI)8.90

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0470

GRAVY Index-0.12

Hydrophobic Moment 0.68

Boman Index-0.00

Instability Index12.45

Aliphatic Index 73.78

Aromaticity 0.0811

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1783.34

LogP -25.88

H-bond Donors 66.0

H-bond Acceptors 61.0

Rotatable Bonds 126.0

Heavy Atoms 279.0

Ring Count 4.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0258239 VERIFIED: YES

Provenance & Taxonomy

OrganismAnolis carolinensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)