Peptide Database

Peptide NameSLAY-screened peptide P2649

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC84H126N22O21S

DescriptionStandard

        RAYFTWPDGCRLLIT
    

Molecular Weight1812.10 Da

Isoelectric Point (pI)8.22

Net Charge (pH 7.0)0.75

Net Charge (pH 7.4) 0.53

Charge Density (pH 7.0) 0.0500

GRAVY Index0.07

Hydrophobic Moment 0.50

Boman Index0.08

Instability Index-5.71

Aliphatic Index 84.67

Aromaticity 0.2000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 699.51

LogP -3.91

H-bond Donors 27.0

H-bond Acceptors 23.0

Rotatable Bonds 53.0

Heavy Atoms 128.0

Ring Count 5.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0191455 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/