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MYP_043282
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Basic Information
Penetratin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Delivery / Targeting ▸ Drug delivery vehicle ▸ Drug delivery
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C107H173N35O21S2
Standard
Sequence
CRQIKIWFQNRRMKWKK
Physicochemical Analysis
2349.87 Da
11.75
6.75
6.52
0.3968
-1.48
0.38
-0.56
44.45
45.88
0.1765
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
979.55
-5.67
37.0
30.0
83.0
165.0
5.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017987 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID24796502 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24796502/
RECORD: Rec_0085122 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: sulfide; Conjugated small molecule: Paclitaxel
Bio-Activity Profile
Anticancer Drug delivery
Cancer cells
PaperSynthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin. Bioorganic & Medicinal Chemistry. 2006 Evidence URLhttps://doi.org/10.1016/j.bmcl.2006.02.035
RECORD: Rec_0131157 VERIFIED: NO
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
not reported
not reported
Bio-Activity Profile
Cell-penetrating peptide
PC-3
Cellular uptake assay
Evidence URLhttps://patents.google.com/patent/US20090186802 PatentUS20090186802
RECORD: Rec_0185690 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24796502 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24796502/
RECORD: Rec_0242124 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24796502 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24796502/
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