Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length358 amino acids

Chemical FormulaC1784H2796N496O519S14

DescriptionStandard

        MRTLESTGTRLCFALAPSSDCSQYCLRSLRGAHRTGMPPWFLERSGEARGIARERRRKDSPHFLTHFRQICEVVKKSSDSHLKPYLQTLPGLEPSHPASLVTLMIDQVAGIDYRLFRAPQVTSKSVDIPIKGEFFSQSQRTPVPFDAPAMMLPQQYDRMVYFAVSEYVFNTASRVYHQAGLLNVTISNEHLAGLFPNMQVQLEASPESEPHLWFTPGKVTIAPVMDVQAFGILPNSSDRRPLFQLRVKTNFSISISVNSDRIVGSVSPESELKLELKHSNIGSVDVEEMETIFNVFAREVIYPSLNAQLKKGFPLPVPRNIFLNSVELQIHEVRSGTWGGSKPCWEVASGAGGDGSKP
    

Molecular Weight39945.21 Da

Isoelectric Point (pI)8.55

Net Charge (pH 7.0)3.38

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.0094

GRAVY Index-0.25

Hydrophobic Moment 0.77

Boman Index0.02

Instability Index46.49

Aliphatic Index 81.93

Aromaticity 0.0866

Extinction Coeff. Reduced 33920.00

Extinction Coeff. Oxidized 34170.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0184886 VERIFIED: NO

Provenance & Taxonomy

OrganismMarmota monax [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence