Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length452 amino acids

Chemical FormulaC2228H3467N555O660S17

DescriptionStandard

        MFPSVIVVLLLISLTCGENPAVQVILTNKGLQYGKNVGAGWIQDKLELITLPDISGGVDIVIGTIYYTLTGITITKCDFPEPSVEFYEDTTGFKTSIAGLSVALTGGWRTNFGAIHDRGSFDMAIFNVDVTSVVELGKDPDGHLSITSVSCDAQVGDVDIEFHGGASWIFQPFVKHFKGRISGEIEERICPNVRESIVNLEYHLQAANVSFDVNEDITFDLPLTGLPVIDASSLNLGLKGEFYSTKTHEEPPFEAQSFTMPEQPGYMLSMGLSEFTLNSASYGYFSAGLLQTSINDSMIPPGSPMHLNTSSMGRFIPQLPKMFPGLLMNLLVYAREAPLFSFHPGAVKLDFQGAVKAFAIQPNGTQTPLFKLNVDSTFSGKVWIADDTLKGSMGMNNFTLTLAASEVGTFKVHDIKTTSQFLKLGIGVALPRMKQAQLINTVLKIEEVSKTL
    

Molecular Weight49132.79 Da

Isoelectric Point (pI)4.97

Net Charge (pH 7.0)-15.70

Net Charge (pH 7.4) -16.53

Charge Density (pH 7.0) -0.0347

GRAVY Index0.13

Hydrophobic Moment 0.74

Boman Index0.19

Instability Index30.62

Aliphatic Index 94.00

Aromaticity 0.0951

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0021987 VERIFIED: NO

Provenance & Taxonomy

OrganismDicentrarchus labrax [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence