Peptide Database

Peptide NameGnRH

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC52H69N13O15

DescriptionStandard

        EHWSFGLSPG
    

Molecular Weight1116.18 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.30

Charge Density (pH 7.0) -0.1076

GRAVY Index-0.50

Hydrophobic Moment 0.21

Boman Index0.26

Instability Index42.52

Aliphatic Index 39.00

Aromaticity 0.2000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 438.66

LogP -3.64

H-bond Donors 15.0

H-bond Acceptors 15.0

Rotatable Bonds 31.0

Heavy Atoms 80.0

Ring Count 5.0

Amide Bonds 9.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0156231 VERIFIED: YES

Provenance & Taxonomy

OrganismOdontesthes bonariensis [Animal]

FamilyGnRH

Tax ID219752

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0382177 VERIFIED: YES

Provenance & Taxonomy

OrganismOdontesthes bonariensis [Animal]

FamilyGnRH

Tax ID219752

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator

Targetand GH from pituitary cells

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0410990 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/