Peptide Database

Peptide NameR-spondin-1

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length245 amino acids

Chemical FormulaC1137H1848N380O348S25

DescriptionStandard

        SRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEALYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCSKKRKLCGFRKGSEERTRRVLHAPGGDHTTCSDTKETRKCTVRRTPCPEGQKRRKGGQGRRENANRHPARKNSKEPRSNSRRHKGQQQPQPGTTGPLTSVGPTWAQ
    

Molecular Weight27210.80 Da

Isoelectric Point (pI)9.52

Net Charge (pH 7.0)23.88

Net Charge (pH 7.4) 22.93

Charge Density (pH 7.0) 0.0975

GRAVY Index-1.01

Hydrophobic Moment 0.52

Boman Index-0.29

Instability Index68.97

Aliphatic Index 39.88

Aromaticity 0.0449

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 22345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0080428 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID10090

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residue at position 117; predicted disulphide bond formation between cysteine residues at positions 128 and 170, 139 and 146, and 179 and 186

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR6 (Human)

Activity3.3 nM

MethodIC50