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MYP_042938
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Basic Information
Bovine myeloid antimicrobial peptide-18 (BMAP-18)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C113H188N34O20
Standard
Sequence
GRFKRFRKKFKKLFKKLS
Physicochemical Analysis
2342.92 Da
12.00
9.75
9.54
0.5418
-1.29
0.82
-0.61
-6.93
43.33
0.2222
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
946.09
-4.98
36.0
30.0
88.0
167.0
4.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0090347 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 66.7%, E 0.0%, T 16.7%, C 16.7% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0110171 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Cytotoxic Antiparasitic Antitrypanosomal
Trypanosoma brucei rhodesiense ViTat 1.1 (procyclic form)
20-30 μg/mL
Percent inhibition; Alamar Blue assay
PaperKilling of trypanosomatid parasites by a modified bovine host defense peptide, BMAP-18 PMID19190729 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19190729/
RECORD: Rec_0111853 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Anti-inflammatory
S. marcescens ATCC 8100
2 μM
MIC
PaperBiological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities PMID34642879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34642879/
RECORD: Rec_0111908 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa ATCC 27853
1 μM
MIC
PMID8910461 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8910461/
RECORD: Rec_0112813 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Myeloid AMP
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania major (amastigote)
2.5 μM
IC50; MTS assay
PaperAntimicrobial peptide action on parasites PMID22664071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22664071/
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