Peptide Database

Peptide NameMTSC29EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC177H282N44O57S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKSEEQQKKN
    

Molecular Weight3970.46 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-1.49

Net Charge (pH 7.4) -1.73

Charge Density (pH 7.0) -0.0479

GRAVY Index-1.91

Hydrophobic Moment 0.69

Boman Index-0.45

Instability Index74.41

Aliphatic Index 50.32

Aromaticity 0.0968

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1721.95

LogP -12.14

H-bond Donors 58.0

H-bond Acceptors 57.0

Rotatable Bonds 147.0

Heavy Atoms 279.0

Ring Count 5.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0413058 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 NL4-3:inhibition of pseudovirus entry in TZM-bl cells

Activity0.0009±0.0002 μM

MethodIC50

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0413666 VERIFIED: YES