Peptide Database

Peptide NameT-197

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-Influenza virus

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC173H287N51O60

DescriptionStandard

        NNSVALDPIDISIELNKAKSDLEESKEWIRRSNQK
    

Molecular Weight4041.44 Da

Isoelectric Point (pI)5.10

Net Charge (pH 7.0)-1.23

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0351

GRAVY Index-1.03

Hydrophobic Moment 0.61

Boman Index-0.28

Instability Index66.32

Aliphatic Index 92.00

Aromaticity 0.0286

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1865.30

LogP -21.22

H-bond Donors 63.0

H-bond Acceptors 59.0

Rotatable Bonds 143.0

Heavy Atoms 284.0

Ring Count 3.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0294445 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-Influenza virus Entry inhibition

TargetHuman parainfluenza virus type 3 (HPIV-3) | HEp-2 cells

Activity1.485 μM

MethodEC50

Half-LifeMammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91. | DOI:10.1073/pnas.93.5.2186 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

RECORD: Rec_0311391 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHIV gp41 fusion inhibitor

Tax ID32630.0

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Antiviral Anti-HIV Anti-Influenza Anti-HPIV3

TargetHuman parainfluenza virus 3

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