Peptide Database

Peptide NameSLAY-screened peptide P3747

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC87H119N17O16

DescriptionStandard

        AVPLLHGVPLFWYF
    

Molecular Weight1658.98 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-0.12

Net Charge (pH 7.4) -0.36

Charge Density (pH 7.0) -0.0084

GRAVY Index1.30

Hydrophobic Moment 0.26

Boman Index0.69

Instability Index29.39

Aliphatic Index 132.14

Aromaticity 0.2857

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 488.74

LogP 2.94

H-bond Donors 16.0

H-bond Acceptors 17.0

Rotatable Bonds 43.0

Heavy Atoms 120.0

Ring Count 8.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0357597 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/