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MYP_042891
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Basic Information
Cupiennin 1a
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
35 amino acids
C176H289N47O44S
Standard
Sequence
GFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME
Physicochemical Analysis
3799.53 Da
10.30
6.76
6.54
0.1931
-0.13
0.69
0.02
25.17
75.43
0.1143
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1511.00
-11.99
51.0
52.0
135.0
268.0
4.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003928 VERIFIED: YES
Provenance & Taxonomy
Cupiennius salei [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Anticancer Antiparasitic Insecticidal
granulocytes
0.47 μM
EC50
PaperCupiennin 1, a New Family of Highly Basic Antimicrobial Peptides in the Venom of the Spider Cupiennius salei (Ctenidae)
RECORD: Rec_0009239 VERIFIED: YES
Provenance & Taxonomy
Cupiennius salei [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal
Staphylococcus aureus ATCC 29213
0.31-0.63 μM
MIC
PMID11792701;17319697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11792701/
RECORD: Rec_0012098 VERIFIED: YES
Provenance & Taxonomy
Cupiennius salei [Animal]
Cupiennin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
Paper蜘蛛抗菌肽研究进展; Advances in spider antimicrobial peptides. [J].生命科学,2014,26(10):1090-1095. DOI:10.13376/j.cbls/2014156. Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37241
RECORD: Rec_0032886 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0035560 VERIFIED: YES
Provenance & Taxonomy
Cupiennius salei [Animal]
cupiennin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Toxin Venom cupiennin family Antibacterial Host defense
PaperPDB 2K38 structural record; NMR; chain A; residues 1-35
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