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MYP_042854
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Basic Information
RTD-2 (RTD 2, rhesus theta-defensin 2)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
18 amino acids
C80H150N36O19S6
Standard
Sequence
GVCRCLCRRGVCRCLCRR
Physicochemical Analysis
2112.67 Da
9.69
5.70
5.41
0.3167
0.18
0.61
-0.46
89.77
75.56
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
929.42
-11.53
43.0
31.0
71.0
141.0
0.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0232212 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
3-16, 5-14, 7-12
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
RECORD: Rec_0237534 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
and yeast forms of Candida albicans 16820 and Cryptococcus neoformans 271A
PMID11675394 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11675394/
RECORD: Rec_0253543 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 BF | JC53-BL cells
5.16 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 | Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI. | J Immunol. 2004 Jul 1;173(1):515-20. | DOI:10.4049/jimmunol.173.1.515 | PMID:15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
RECORD: Rec_0261700 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0261896 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
3-16, 5-14, 7-12
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 B:inhibition of infection in JC53-BL cells
1.78±0.57 μg/mL
IC50
PaperPubMed PMID: 15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
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