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MYP_042751
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Basic Information
Gastric inhibitory polypeptide
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
42 amino acids
C226H338N60O66S
Standard
Sequence
YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
Physicochemical Analysis
4983.53 Da
6.92
-0.07
-0.38
-0.0016
-0.80
0.36
-0.05
33.32
69.76
0.1429
13980.00
13980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2084.97
-18.11
70.0
69.0
168.0
353.0
10.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0256994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GIP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
2-aminobutyric acid (Abu)
Bio-Activity Profile
Insulin secretion stimulation Glucose clearance
0.0368±0.0016 μM
EC50
Human plasma, in vitro; 25560 s
PMID15246869 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15246869/
RECORD: Rec_0310204 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
glucagon family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone glucagon family
PaperPDB 2OBU structural record; NMR; chain A; residues 1-42
RECORD: Rec_0312837 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Gastric inhibitory polypeptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Receptor modulation
Experimental: 6 hours; /21600 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Gastric inhibitory polypeptide (Homo sapiens): PMID 6745415##15012592 PMID6745415;15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6745415/
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