Peptide Database

Peptide NameSLAY-screened peptide P5031

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H169N25O26S2

DescriptionStandard

        SPVMSKYAIPSYRPMFPPIK
    

Molecular Weight2309.79 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)2.46

Net Charge (pH 7.4) 2.24

Charge Density (pH 7.0) 0.1228

GRAVY Index-0.18

Hydrophobic Moment 0.44

Boman Index0.10

Instability Index95.52

Aliphatic Index 58.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 787.36

LogP -3.95

H-bond Donors 26.0

H-bond Acceptors 31.0

Rotatable Bonds 66.0

Heavy Atoms 162.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0293820 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/