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MYP_042679
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Basic Information
human Histatin 1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
32 amino acids
C178H258N64O48
Standard
Sequence
DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN
Physicochemical Analysis
4062.35 Da
9.99
5.37
4.80
0.1677
-2.30
0.41
-0.58
46.75
15.31
0.1562
5960.00
5960.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1857.55
-20.34
68.0
60.0
135.0
290.0
12.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0091679 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Histatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0115481 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
RECORD: Rec_0178885 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans. Structure: in 50% DMSO, Nmt found a turn
PaperHistatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.
RECORD: Rec_0205784 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans (98.5±0.5 % inhibition at 54 nmol)
PaperPubMed PMID: 3286634 PMID3286634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3286634/
RECORD: Rec_0213388 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Evidence URLhttps://patents.google.com/patent/US6531573B1/en PatentUS 6531573 B1
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