Peptide Database

Peptide NameCurvacin A / sakacin A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC194H285N53O58S3

DescriptionStandard

        RSYDNGIYCNNSKCWFNWGEAKENIAGIVISGWASGLAGM
    

Molecular Weight4383.85 Da

Isoelectric Point (pI)6.17

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.50

Charge Density (pH 7.0) -0.0064

GRAVY Index-0.21

Hydrophobic Moment 0.36

Boman Index0.15

Instability Index25.69

Aliphatic Index 66.00

Aromaticity 0.1500

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1808.26

LogP -18.94

H-bond Donors 65.0

H-bond Acceptors 61.0

Rotatable Bonds 141.0

Heavy Atoms 308.0

Ring Count 9.0

Amide Bonds 44.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0115915 VERIFIED: YES

Provenance & Taxonomy

OrganismEnterococcus faecium [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)