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MYP_042446
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Basic Information
P21R8
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LDLTYEMLSLQXVVKXLNESY
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0347253 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' (position: 12 and 16) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (12) and X (16) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV; Huh-7 cells
0.26±0.05 μM
EC50; cell-cell fusion inhibition
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0360151 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 12,16
Bio-Activity Profile
Antiviral
Q1020R-MERS-CoV pseudovirus
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0401728 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 12,16
Bio-Activity Profile
Antiviral
MERS-CoV
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0412688 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' (position: 12 and 16) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (12) and X (16) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antiviral
WT MERS-CoV pseudovirus; Calu-3 cells
3.03±0.29 μM
EC50; pseudovirus infection inhibition
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0418863 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 12 and 16 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV; Huh-7 cells
20.6±3.3 μM
EC50; cell-cell fusion inhibition
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
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