MYP_042446
P21R8
Anticancer
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Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antiviral
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Antiviral mechanism
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Membrane / Ion-channel modulation
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Sodium channel modulation
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Sodium channel inhibitor
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
LDLTYEMLSLQXVVKXLNESY
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0060979
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' at position 12 and 16 are R5 amino acids. ②X (12) and X (16) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0094299
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' (position: 12 and 16) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (12) and X (16) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial
Q1020R-MERS-CoV pseudovirus:inhibition of pseudovirus infection in calu-3 cells
1.98±0.28 μM
EC50
RECORD: Rec_0098601
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 12,16
Bio-Activity Profile
MERS-CoV PsV
RECORD: Rec_0118665
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 12,16
Bio-Activity Profile
Human hepatocellular carcinoma Huh7
50-60 % Cytotoxicity
Cytotoxicity
RECORD: Rec_0178637
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 12,16
Bio-Activity Profile
Cov-Q1020H PsV
Showing 5 records on this page · Page 1 of 5