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MYP_042415
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Basic Information
Brevinin-2HS2A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
75 amino acids
C362H607N91O114S5
Standard
Sequence
MFTLKKPLLLLFFLGTISLSLCQEERDADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC
Physicochemical Analysis
8218.56 Da
4.88
-3.51
-3.80
-0.0468
0.07
0.60
0.05
46.47
110.53
0.0400
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3313.27
-28.67
117.0
116.0
293.0
572.0
4.0
76.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0291243 VERIFIED: YES
Provenance & Taxonomy
Odorrana hainanensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
slime mold 090223
37.5 μM
MIC
PaperPubMed PMID: 22450466 PMID22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22450466/
RECORD: Rec_0321024 VERIFIED: YES
Provenance & Taxonomy
Odorrana hainanensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
faecalis X29
9.5 μM
MIC
PaperPubMed PMID: 22450466 PMID22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22450466/
RECORD: Rec_0364071 VERIFIED: YES
Provenance & Taxonomy
Odorrana hainanensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
albicans ATCC 2002
19 μM
MIC
PaperPubMed PMID: 22450466 PMID22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22450466/
RECORD: Rec_0373850 VERIFIED: YES
Provenance & Taxonomy
Odorrana hainanensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
300 μM
LC50
PaperPubMed PMID: 22450466 PMID22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22450466/
RECORD: Rec_0388451 VERIFIED: NO
Provenance & Taxonomy
Odorrana hainanensis [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Antifungal Fungicide Anti-Candida Cytolytic Hemolytic Non-ribosomal
Qualitative functional evidence
PMID22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22450466/; https://www.uniprot.org/uniprotkb/E7EKE0/entry; https://bblserver.org.in/ampdb/
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