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MYP_042193
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
4 amino acids
C32H36N4O8
Standard
Sequence
YPYY
Physicochemical Analysis
604.65 Da
5.52
-0.24
-0.45
-0.0607
-1.38
0.06
0.23
69.20
0.00
0.7500
4470.00
4470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
202.52
1.20
7.0
8.0
12.0
44.0
4.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0096945 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
kappa-Casein-derived
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-IV inhibitory Antidiabetic
Dipeptidyl peptidase-IV (DPP-IV)
194.4 μM
IC50
PaperSusceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis | Nongonierma, A. et al. | DOI: 10.1016/j.foodchem.2013.08.097 Evidence URLhttps://www.uniprot.org/uniprotkb/P07498/entry
RECORD: Rec_0202647 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperAntihypertensive peptides from food proteins: a review PMID22249830 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22249830/
RECORD: Rec_0203508 VERIFIED: YES
Provenance & Taxonomy
Jatropha curcas [Plant]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
15.9 mmHg
SBP decrease
PaperEffect of Jatropha curcas Peptide Fractions on the Angiotensin I-Converting Enzyme Inhibitory Activity PMID24224169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24224169/
RECORD: Rec_0220946 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Contractile
PaperChiba H., Tani F., Yoshikawa M.. Opioid antagonist peptides derived from kappa-casein. J. Dairy Res., 56, 363-366, 1986.
RECORD: Rec_0229314 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
90.9
IC50
PaperTsai J.-S., Chen T.-J., Pan B. S., Gong S.-D., Chung M.-Y.. Antihypertensive effect of bioactive peptides produced by protease-facilitated lactic acid fermentation of milk. Food Chem., 106, 552-558, 2008.
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