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MYP_042193
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
4 amino acids
C32H36N4O8
Standard
Sequence
YPYY
Physicochemical Analysis
604.65 Da
5.52
-0.24
-0.45
-0.0607
-1.38
0.06
0.23
69.20
0.00
0.7500
4470.00
4470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
202.52
1.20
7.0
8.0
12.0
44.0
4.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005333 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0018519 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
kappa-Casein-derived
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
90.9 μM
IC50
PaperAntihypertensive effect of bioactive peptides produced by protease-facilitated lactic acid fermentation of milk | Tsai, J-S. et al. | DOI: 10.1016/j.foodchem.2007.06.039 Evidence URLhttps://www.uniprot.org/uniprotkb/P07498/entry
RECORD: Rec_0049028 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Casoxin
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid receptor ligand Opioid antagonist
PaperOpioid antagonist peptides derived from kappa-casein | Chiba, H. et al. | DOI: 10.1017/s0022029900028818 Evidence URLhttps://www.uniprot.org/uniprotkb/P07498/entry
RECORD: Rec_0054177 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
Dipeptidyl peptidase IV
149.4
IC50
PaperNongonierma A. B., FitzGerald R. J.. Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chemistry 145, 845-852, 2014.
RECORD: Rec_0058319 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
15.9 mmHg
SBP decrease
PaperAntihypertensive peptides from food proteins: a review. PMID22249830 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22249830/
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