Peptide Database

Peptide NameMelanin-concentrating hormone

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC95H153N31O25S4

DescriptionStandard

        RDTMRCMVGRVYRPCWEV
    

Molecular Weight2257.68 Da

Isoelectric Point (pI)8.95

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.51

Charge Density (pH 7.0) 0.0968

GRAVY Index-0.47

Hydrophobic Moment 0.68

Boman Index-0.28

Instability Index16.38

Aliphatic Index 48.33

Aromaticity 0.1111

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 927.68

LogP -7.44

H-bond Donors 37.0

H-bond Acceptors 31.0

Rotatable Bonds 71.0

Heavy Atoms 155.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023827 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis mossambicus [Animal]

FamilyMelanin-concentrating hormone

Tax ID8127

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-15

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min

RECORD: Rec_0189800 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0238082 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis mossambicus [Animal]

FamilyMelanin-concentrating hormone

Tax ID8127

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-15

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Targetthe control of the hypothalamo-pituitary adrenal gland

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min

RECORD: Rec_0320784 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis mossambicus [Animal]

FamilyMelanin-concentrating hormone

Tax ID8127

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Neuromodulator