Peptide Database

Peptide NameSLAY-screened peptide P5497

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H157N35O31S

DescriptionStandard

        NRTGNELRNFSLCNHHDWVL
    

Molecular Weight2425.64 Da

Isoelectric Point (pI)6.91

Net Charge (pH 7.0)-0.07

Net Charge (pH 7.4) -0.39

Charge Density (pH 7.0) -0.0036

GRAVY Index-0.92

Hydrophobic Moment 0.57

Boman Index-0.19

Instability Index5.05

Aliphatic Index 73.00

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1100.59

LogP -12.40

H-bond Donors 39.0

H-bond Acceptors 34.0

Rotatable Bonds 78.0

Heavy Atoms 171.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0052760 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/