Peptide Database

Peptide NameCaerin-2.2

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC108H189N31O34

DescriptionStandard

        GLVSSIGRALGGLLADVVKSKEQPA
    

Molecular Weight2465.84 Da

Isoelectric Point (pI)8.59

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0305

GRAVY Index0.37

Hydrophobic Moment 0.57

Boman Index0.17

Instability Index40.80

Aliphatic Index 124.80

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1045.25

LogP -11.57

H-bond Donors 36.0

H-bond Acceptors 35.0

Rotatable Bonds 84.0

Heavy Atoms 173.0

Ring Count 1.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0386107 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria splendida [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

TargetMIC 50 ug/ml, Staphylococcus aureus ATCC 25923

Activity>100 μg/mL

MethodMIC

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