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MYP_042090
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Basic Information
Caerin-2.2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C108H189N31O34
Standard
Sequence
GLVSSIGRALGGLLADVVKSKEQPA
Physicochemical Analysis
2465.84 Da
8.59
0.76
0.55
0.0305
0.37
0.57
0.17
40.80
124.80
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1045.25
-11.57
36.0
35.0
84.0
173.0
1.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006080 VERIFIED: NO
Provenance & Taxonomy
Litoria gilleni [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCaerin-2.2 Evidence URLhttps://www.uniprot.org/uniprotkb/P62570/entry
RECORD: Rec_0027854 VERIFIED: YES
Provenance & Taxonomy
Litoria gilleni [Animal]
Caerin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial nNOS inhibitor
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0028770 VERIFIED: YES
Provenance & Taxonomy
Litoria gilleni [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pasteurella multocida
25 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0064774 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Streptococcus uberis
>100 μg/mL
MIC
PaperPeptides from Australian frogs. The structures of the caerins from Litoria caerula.
RECORD: Rec_0100696 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus epidermidis
>100 μg/mL
MIC
PaperPeptides from Australian frogs. The structures of the caerins from Litoria caerula.
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