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MYP_041972
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Basic Information
Defensin def2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
37 amino acids
C188H279N55O46S6
Standard
Sequence
GGYYCPFFQDKCHRHCRSFGRKAGYCGGFLKKTCICV
Physicochemical Analysis
4237.96 Da
9.27
5.87
5.47
0.1586
-0.31
0.80
-0.05
50.03
31.62
0.1892
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1630.81
-15.34
65.0
60.0
136.0
295.0
10.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012810 VERIFIED: NO
Provenance & Taxonomy
Ixodes ricinus [Animal]; Ornithodoros savignyi [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0043107 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Mu50
32 μg/mL
MIC
PMID27531221 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27531221/
RECORD: Rec_0102656 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus luteus
50 μM
MIC
PMID21504572 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21504572/
RECORD: Rec_0130593 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Ir
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PaperParasit Vectors. 2011 Apr 19;4:63. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102633/ Evidence URLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC3102633/
RECORD: Rec_0156110 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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