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MYP_041717
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Basic Information
Dolabellanin B2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
33 amino acids
C163H248N48O48S7
Standard
Sequence
SHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ
Physicochemical Analysis
3872.46 Da
7.71
0.77
0.29
0.0233
-0.60
0.48
-0.09
74.86
29.70
0.0909
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1546.85
-17.42
56.0
60.0
129.0
266.0
8.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004209 VERIFIED: YES
Provenance & Taxonomy
Dolabella auricularia [Animal]
Dolabellanin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperDev Comp Immunol. 2003 Apr;27(4):305-11 | http://www.ncbi.nlm.nih.gov/pubmed/12590964 PMID12590964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12590964/
RECORD: Rec_0008237 VERIFIED: YES
Provenance & Taxonomy
Dolabella auricularia [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Saccharomyces cerevisiae
PMID12590964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12590964/
RECORD: Rec_0014329 VERIFIED: YES
Provenance & Taxonomy
Dolabella auricularia [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Up to two of the methionines may be oxidized to methionine sulfoxides
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
pombe IFO1628
PMID12590964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12590964/
RECORD: Rec_0025821 VERIFIED: YES
Provenance & Taxonomy
Dolabella auricularia [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Toxicity
Staphylococcus aureus
10 μg/mL
LC50
PaperA novel antimicrobial peptide from the sea hare Dolabella auricularia
RECORD: Rec_0029690 VERIFIED: YES
Provenance & Taxonomy
Dolabella auricularia [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Up to two of the methionines may be oxidized to methionine sulfoxides
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli DH5α
40 μg/mL
MIC
PMID12590964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12590964/
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