Peptide Database

Peptide NameRibosome-inactivating protein lyophyllin

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Antiviral

Antiviral ▸ Anti-HIV

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme modulation ▸ Enzyme inhibition ▸ Protein Synthesis Inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length50 amino acids

Chemical FormulaC238H376N68O71S

DescriptionStandard

        ITFQGCSPARQTVITNAITRARADVRAAVSALPTKAPVSTFSTWFGVYND
    

Molecular Weight5358.01 Da

Isoelectric Point (pI)10.04

Net Charge (pH 7.0)2.75

Net Charge (pH 7.4) 2.53

Charge Density (pH 7.0) 0.0551

GRAVY Index0.10

Hydrophobic Moment 0.47

Boman Index0.08

Instability Index33.57

Aliphatic Index 76.20

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2241.98

LogP -27.06

H-bond Donors 81.0

H-bond Acceptors 75.0

Rotatable Bonds 165.0

Heavy Atoms 378.0

Ring Count 9.0

Amide Bonds 53.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0270969 VERIFIED: NO

Provenance & Taxonomy

OrganismLyophyllum shimeji [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Fungicide Antiviral Anti-HIV Hydrolase Protein Synthesis Inhibitor Toxin Anticancer Cytotoxic Non-hemolytic Non-ribosomal

TargetP.piricola

MethodQualitative functional evidence