Peptide Database

Peptide NameSLAY-screened peptide P344

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC79H122N28O20S2

DescriptionStandard

        VCDYHYNIHCLRRR
    

Molecular Weight1848.12 Da

Isoelectric Point (pI)8.90

Net Charge (pH 7.0)1.89

Net Charge (pH 7.4) 1.54

Charge Density (pH 7.0) 0.1348

GRAVY Index-0.86

Hydrophobic Moment 0.40

Boman Index-0.39

Instability Index212.79

Aliphatic Index 76.43

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 805.53

LogP -6.72

H-bond Donors 32.0

H-bond Acceptors 26.0

Rotatable Bonds 58.0

Heavy Atoms 129.0

Ring Count 4.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0213171 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/