Peptide Database

Peptide NameSLAY-screened peptide P5803

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC86H132N26O24S3

DescriptionStandard

        NLRPDAARDFCTCHFML
    

Molecular Weight2010.32 Da

Isoelectric Point (pI)6.73

Net Charge (pH 7.0)-0.17

Net Charge (pH 7.4) -0.45

Charge Density (pH 7.0) -0.0100

GRAVY Index-0.08

Hydrophobic Moment 0.46

Boman Index-0.06

Instability Index55.45

Aliphatic Index 57.65

Aromaticity 0.1176

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 810.53

LogP -7.41

H-bond Donors 30.0

H-bond Acceptors 28.0

Rotatable Bonds 62.0

Heavy Atoms 139.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034152 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/