Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length308 amino acids

Chemical FormulaC1558H2426N376O448S14

DescriptionStandard

        MKHGVQVGMKIMEEMAKEIVIPDLKGSESLEFLKIDYVKYNFSNIKINAFSLPNTSLAFVPGVGIRALSNHGTANISANWDVRAPLFVLYNSFAEPMEKPILRNLNEMLCPIVMDQVEALNVNISALEVLTKIDNYTVLDCSLLSPPEVTENHLDLNLKGAFYPLESLVDPPFLPAPFELPENRDSMLYIGISEYFFKSASFAHFVTGALEVTLSTKEIAEIYILSQPFMLQIMATGPPVVNLHSNNFSLEFPAAVIMLTQLQNSTTVEHIVSMDFVSLGIQGGSLWAPILFLLGITGQQPLGVWSEG
    

Molecular Weight34041.09 Da

Isoelectric Point (pI)4.67

Net Charge (pH 7.0)-15.94

Net Charge (pH 7.4) -16.57

Charge Density (pH 7.0) -0.0518

GRAVY Index0.28

Hydrophobic Moment 0.73

Boman Index0.23

Instability Index33.89

Aliphatic Index 107.60

Aromaticity 0.0942

Extinction Coeff. Reduced 28420.00

Extinction Coeff. Oxidized 28545.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0119901 VERIFIED: NO

Provenance & Taxonomy

OrganismNeotoma lepida [Animal]

FamilyBPI/LBP

Tax ID56216

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria