Peptide Database

Peptide NameProgonadoliberin-1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC298H476N88O90S3

DescriptionStandard

        QHWSYGLRPGGKRNAKNVIDSFQEIAKEVDQPVEPKCCGCIVHQSHSPLRDLKAALESLIE
    

Molecular Weight6827.70 Da

Isoelectric Point (pI)7.01

Net Charge (pH 7.0)0.01

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) 0.0001

GRAVY Index-0.57

Hydrophobic Moment 0.73

Boman Index-0.09

Instability Index63.91

Aliphatic Index 83.11

Aromaticity 0.0492

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2870.11

LogP -29.29

H-bond Donors 99.0

H-bond Acceptors 96.0

Rotatable Bonds 228.0

Heavy Atoms 479.0

Ring Count 11.0

Amide Bonds 66.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0114067 VERIFIED: NO

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyProgonadoliberin

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods10:Glycine amide

Bio-Activity Profile

Function

Hormone Endocrine Reproductive regulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0236200 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0322551 VERIFIED: NO

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyGnRH

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Other ModsGly10 Amidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide