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MYP_041447
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Basic Information
Cycloviolacin-O11 (Cyclotide c2; Plant defensin)
Antimicrobial
Insecticidal/Pest control ▸ Insecticidal activity
Standard
31 amino acids
C138H224N36O41S6
Standard
Sequence
GTLPCGESCVWIPCISAVVGCSCKSKVCYKN
Physicochemical Analysis
3235.86 Da
8.33
1.70
1.40
0.0548
0.55
0.28
0.21
24.26
78.39
0.0645
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1214.36
-13.64
48.0
49.0
101.0
221.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028617 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-21; 9-23; 14-28
Bio-Activity Profile
Insecticidal
PaperPubMed PMID: 16872274 | PubMed PMID: 10600388 PMID16872274;10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0084917 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperPlant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0169784 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0185204 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0289717 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Enzymatic-digestion
PaperA novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability | PubMed PMID 10600380 PMID10600380 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600380/
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