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MYP_041435
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Basic Information
Tat
Anticancer
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Standard
14 amino acids
C73H136N36O17S
Standard
Sequence
CGRKKRRQRRRPPQ
Physicochemical Analysis
1822.16 Da
12.00
7.75
7.53
0.5534
-3.06
0.49
-1.35
210.34
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
933.66
-12.36
36.0
26.0
64.0
127.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0029836 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22100438 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100438/
RECORD: Rec_0092705 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-).
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24892976 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24892976/
RECORD: Rec_0139683 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: doxorubicin
Bio-Activity Profile
Anticancer
HepG2, Cancer cells
PaperJournal of controlled release : official journal of the Controlled Release Society. 2014 PMID24892976 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24892976/
RECORD: Rec_0191757 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Palmitoylation
Amidation
Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-).
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24892976 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24892976/
RECORD: Rec_0276360 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
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