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MYP_041364
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Basic Information
Short α-helical peptides
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C80H154N20O15
Standard
Sequence
GIIKKIIKKIIKKI
Physicochemical Analysis
1636.20 Da
10.70
5.75
5.54
0.4110
0.55
0.87
0.08
-33.16
195.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
597.74
0.43
21.0
21.0
65.0
115.0
0.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0087207 VERIFIED: YES
Provenance & Taxonomy
Alpha-helical proteins [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
250 μM
HC50
PaperPubMed PMID: 24246647 PMID24246647 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24246647/
RECORD: Rec_0141199 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Bacillus subtilis ATCC 23857
8 μM
MIC
PaperHigh Therapeutic Index alpha-Helical AMPs and Their Therapeutic Potential on Bacterial Lung and Skin Wound Infections
RECORD: Rec_0166637 VERIFIED: YES
Provenance & Taxonomy
Alpha-helical proteins [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
HL-60 Approx
90 %
Cytotoxicity
PaperPubMed PMID: 24246647 PMID24246647 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24246647/
RECORD: Rec_0181045 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antibiofilm
Cryptococcus neoformans
3.1±1 μM
MIC
PMID34626966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34626966/
RECORD: Rec_0186670 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antibiofilm
C. parapsilosis
25±2 μM
MIC
PMID34626966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34626966/
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