Peptide Database

Peptide NameBasic phospholipase A2 homolog myotoxin II (MjTX-II) (svPLA2 homolog) (Basic phospholipase A2 homolog 2) (M-VI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Enzyme / Catalytic activity ▸ Hydrolase ▸ Lipase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length122 amino acids

Chemical FormulaC603H953N167O179S15

DescriptionStandard

        SLFELGKMILQETGKNPAKSYGVYGCNCGVGGRGKPKDATDRCCYVHKCCYKKLTGCDPKKDRYSYSWKDKTIVCGENNSCLKELCECDKAVAICLRENLDTYNKKYRYNYLKPFCKKADPC
    

Molecular Weight13887.00 Da

Isoelectric Point (pI)8.95

Net Charge (pH 7.0)9.41

Net Charge (pH 7.4) 8.88

Charge Density (pH 7.0) 0.0771

GRAVY Index-0.74

Hydrophobic Moment 0.57

Boman Index-0.19

Instability Index20.85

Aliphatic Index 54.34

Aromaticity 0.1066

Extinction Coeff. Reduced 20400.00

Extinction Coeff. Oxidized 21275.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5660.34

LogP -57.72

H-bond Donors 210.0

H-bond Acceptors 205.0

Rotatable Bonds 469.0

Heavy Atoms 964.0

Ring Count 20.0

Amide Bonds 129.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0082410 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops moojeni [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Antiparasitic Anti-Gram-negative Toxin Non-hemolytic

TargetLeishmania sp.

RECORD: Rec_0140021 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops moojeni [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Antiparasitic Anti-Gram-negative Toxin Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0219655 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops moojeni [Animal]

Familyphospholipase A2 family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide26-116; 28-44; 43-95; 49-122; 50-88; 57-81; 75-86

Bio-Activity Profile

Function

Toxin Venom Phospholipase A2 family Phospholipase A2

RECORD: Rec_0236790 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops moojeni [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Antiparasitic Anti-Gram-negative Toxin Non-hemolytic

TargetS. mansoni

RECORD: Rec_0381674 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops moojeni [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Antiparasitic Anti-Gram-negative Toxin Non-hemolytic

TargetCandida albicans