‹ ›
MYP_041274
← PREVIOUS NEXT → BACK
Basic Information
Api795 apidaecin petide derivative
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XIXIXRPVYXPRPRPPHPRL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0397816 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu=N , N , N ', N'-tetramethylguanidino)
None
X=Orn
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
0 %
Hemolysis
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0419244 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Tetramethylguanidino
O = L-ornithine, I=Ile-Orn-motifs
Bio-Activity Profile
Cytotoxicity
HEK293
>600 μg/mL
IC50
Mouse serum: Half-life time (mouse serum )=354 min
PaperBluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R. N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa Front Cell Dev Biol. 2016 May 10;4:39 PMID:27243004 https://pubmed.ncbi.nlm.nih.gov/27243004/ PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
FIRST PREV 1 ... 6 7 8
Showing 2 records on this page · Page 8 of 8