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MYP_041274
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Basic Information
Api795 apidaecin petide derivative
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XIXIXRPVYXPRPRPPHPRL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010903 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
None
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
HEK293
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0020592 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu=N , N , N ', N'-tetramethylguanidino)
None
X=Orn
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
600 μg/mL
IC50
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0029682 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Gu (N
L-Ornithine at 1,3,5,10; L-Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli BW25113
4 μg/mL
MIC
PMID29309652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29309652/
RECORD: Rec_0031977 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
None
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa(DSM 9644)
8 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0042066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Tetramethylguanidino
O = L-ornithine, I=Ile-Orn-motifs
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 1117 (50% MHB)
8 μg/mL
MIC
Mouse serum: Half-life time (mouse serum )=354 min
PaperBluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R. N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa Front Cell Dev Biol. 2016 May 10;4:39 PMID:27243004 https://pubmed.ncbi.nlm.nih.gov/27243004/ PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
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