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MYP_041269
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Basic Information
hepcidin TH1-5
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C94H153N29O24S8
Standard
Sequence
GIKCRFCCGCCTPGICGVCCRF
Physicochemical Analysis
2329.92 Da
8.54
2.68
2.36
0.1218
1.00
0.33
0.18
12.79
48.64
0.0909
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
835.68
-9.68
38.0
35.0
72.0
155.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0185317 VERIFIED: NO
Provenance & Taxonomy
Actinopterygii [Animal]
Hepcidin
7898
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0203872 VERIFIED: YES
Provenance & Taxonomy
Oreochromis mossambicus [Animal]
Hepcidin
8127
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
disulfide-stabilized; exact pairings not extracted
Bio-Activity Profile
Anticancer Antimicrobial
HT1080, HeLa, HepG2
30-100 μg/mL
PaperTilapia (Oreochromis mossambicus) antimicrobial peptide, hepcidin 1-5, shows antitumor activity in cancer cells PMID21093514 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21093514/
RECORD: Rec_0223325 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0325922 VERIFIED: NO
Provenance & Taxonomy
Actinopterygii [Animal]
Hepcidin
7898
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0342857 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
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