Peptide Database

Peptide NameSomatostatin-25

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitory neuropeptide

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Inhibitory neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC129H195N37O36S2

DescriptionStandard

        SVDNLPPRERKAGCKNFYWKGFTSC
    

Molecular Weight2904.28 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)2.44

Net Charge (pH 7.4) 2.20

Charge Density (pH 7.0) 0.0976

GRAVY Index-0.91

Hydrophobic Moment 0.43

Boman Index-0.21

Instability Index28.50

Aliphatic Index 31.20

Aromaticity 0.1600

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1203.49

LogP -12.58

H-bond Donors 44.0

H-bond Acceptors 41.0

Rotatable Bonds 92.0

Heavy Atoms 204.0

Ring Count 7.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0090860 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus kisutch [Animal]

FamilySomatostatin

Tax ID8019

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide14-25

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0268870 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus kisutch [Animal]

FamilySomatostatin

Tax ID8019

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide14-25

Bio-Activity Profile

Function

Hormone Inhibitory neuropeptide

RECORD: Rec_0347143 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/