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MYP_041216
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Basic Information
LCB3
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
64 amino acids
C346H556N90O106S2
Standard
Sequence
NDDELHMLMTDLVYEALHFAKDEEIKKRVFQLFELADKAYKNNDRQKLEKVVEELKELLERLLS
Physicochemical Analysis
7736.79 Da
4.94
-5.04
-5.38
-0.0788
-0.66
0.70
-0.17
17.58
103.59
0.0781
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3241.01
-21.85
109.0
105.0
277.0
544.0
7.0
68.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0093590 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Miniprotein inhibitor
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
0.0000481 μM
IC50
PaperDe novo design of picomolar SARS-CoV-2 miniprotein inhibitors PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0206603 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2
PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0383162 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells
0.000048 μM
IC50
PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0390635 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Binding inhibition
SARS-CoV-2 | E6 cells
0.0000481 μM
IC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperDe novo design of picomolar SARS-CoV-2 miniprotein inhibitors. | Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. | Science. 2020 Oct 23;370(6515):426-431. | DOI:10.1126/science.abd9909 | PMID:32907861 PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/