Peptide Database

Peptide NameSARS-CoV-2-S(1168-1203)-GSGSGC

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length42 amino acids

Chemical FormulaC187H316N54O69S

DescriptionStandard

        DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGSGSGC
    

Molecular Weight4456.89 Da

Isoelectric Point (pI)4.20

Net Charge (pH 7.0)-4.24

Net Charge (pH 7.4) -4.47

Charge Density (pH 7.0) -0.1009

GRAVY Index-0.16

Hydrophobic Moment 0.70

Boman Index0.03

Instability Index37.93

Aliphatic Index 118.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2034.24

LogP -25.53

H-bond Donors 68.0

H-bond Acceptors 66.0

Rotatable Bonds 158.0

Heavy Atoms 311.0

Ring Count 0.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0211714 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2 Cytotoxic

TargetVero E6 cells

RECORD: Rec_0218904 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2_S943P | 293T cells

Activity0.006±0.004 μM

MethodIC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h

PaperInhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain. | Outlaw VK, Bovier FT, Mears MC, Cajimat MN, Zhu Y, Lin MJ, Addetia A, Lieberman NAP, Peddu V, Xie X, Shi PY, Greninger AL, Gellman SH, Bente DA, Moscona A, Porotto M. | mBio. 2020 Oct 20;11(5):e01935-20. | DOI:10.1128/mBio.01935-20 | PMID:33082259 PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/

RECORD: Rec_0238786 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-MERS-CoV Fusion inhibition

TargetMERS-CoV | 293T cells

Activity0.035±0.01 μM

MethodIC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h

PaperInhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain. | Outlaw VK, Bovier FT, Mears MC, Cajimat MN, Zhu Y, Lin MJ, Addetia A, Lieberman NAP, Peddu V, Xie X, Shi PY, Greninger AL, Gellman SH, Bente DA, Moscona A, Porotto M. | mBio. 2020 Oct 20;11(5):e01935-20. | DOI:10.1128/mBio.01935-20 | PMID:33082259 PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/

RECORD: Rec_0238940 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2_S943P | 293T cells

Activity0.075±0.042 μM

MethodIC90

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h

PaperInhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain. | Outlaw VK, Bovier FT, Mears MC, Cajimat MN, Zhu Y, Lin MJ, Addetia A, Lieberman NAP, Peddu V, Xie X, Shi PY, Greninger AL, Gellman SH, Bente DA, Moscona A, Porotto M. | mBio. 2020 Oct 20;11(5):e01935-20. | DOI:10.1128/mBio.01935-20 | PMID:33082259 PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/

RECORD: Rec_0245478 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

Targetinhibition of infection in Vero E6 cells

MethodIC50

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